Table 1 Optimal sampling times (h) and sampling windows for each drug

Mefloquine (8.3 mg/kg at 0, 24 and 48 h)

Group 1:

(n = 50)

(2.35, 4.11)

(39.4, 47.6)

(139, 158)

(457, 546)

(988, 1058)

Group 2:

(n = 50)

(1.49, 2.81)

(26.7, 29.6)

(62.7, 75.8)

(139, 158)

(456, 593)

Mefloquine (15 mg/kg at 24 h, 10 mg/kg at 48 h)

Group 1:

(n = 50)

(25.8, 27.8)

(60.8, 71.7)

(134, 158)

(501, 593)

(971, 1058)

Group 2:

(n = 50)

(25.8, 27.5)

(60.5, 71.6)

(60.5, 71.7)

(141, 158)

(650, 776)

Lumefantrine (12 mg/kg at 0, 8, 24, 36, 48 and 60 h)

Group 1:

(n = 50)

(1.78, 2.78)

(28.1, 31.7)

(86.9, 110)

(132, 159)

(231, 310)

Group 2:

(n = 50)

(10.1, 13.4)

(37.7, 41.6)

(52.3, 56.6)

(130, 149)

(203, 261)

Piperaquine (18 mg/kg at 0, 24 and 48 h)

Group 1:

(n = 50)

(0.10, 0.61)

(29.1, 31.9)

(72.3, 84.9)

(138, 156)

(652, 747)

Group 2:

(n = 50)

(2.15, 3.95)

(24.0, 24.6)

(138, 155)

(259, 382)

(1204, 1322)

Desethylamodiaquine (10 mg/kg of amodiaquine at 0, 24 and 48 h)

Group 1:

(n = 50)

(7.03, 10.1)

(24.0, 24.1)

(129, 157)

(339, 398)

(599, 651)

Group 2:

(n = 50)

(0.38, 1.36)

(24.0, 24.1)

(88.4, 106)

(129, 157)

(316, 397)