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Table 1 Optimal sampling times (h) and sampling windows for each drug

From: Optimal designs for population pharmacokinetic studies of the partner drugs co-administered with artemisinin derivatives in patients with uncomplicated falciparum malaria

Drug   Optimal times
   (sampling windows)
Mefloquine (8.3 mg/kg at 0, 24 and 48 h) Group 1: 3.22 43.0 147* 496 1035
(n = 50) (2.35, 4.11) (39.4, 47.6) (139, 158) (457, 546) (988, 1058)
Group 2: 2.02 28.0 67.8 147* 538
(n = 50) (1.49, 2.81) (26.7, 29.6) (62.7, 75.8) (139, 158) (456, 593)
Mefloquine (15 mg/kg at 24 h, 10 mg/kg at 48 h) Group 1: 26.5 66.9 147* 544 1011
(n = 50) (25.8, 27.8) (60.8, 71.7) (134, 158) (501, 593) (971, 1058)
Group 2: 26.5 66.3 66.5 147* 694
(n = 50) (25.8, 27.5) (60.5, 71.6) (60.5, 71.7) (141, 158) (650, 776)
Lumefantrine (12 mg/kg at 0, 8, 24, 36, 48 and 60 h) Group 1: 2.28 30.3 100 147* 267
(n = 50) (1.78, 2.78) (28.1, 31.7) (86.9, 110) (132, 159) (231, 310)
Group 2: 11.6 37.7 53.7 147* 218
(n = 50) (10.1, 13.4) (37.7, 41.6) (52.3, 56.6) (130, 149) (203, 261)
Piperaquine (18 mg/kg at 0, 24 and 48 h) Group 1: 0.18 30.0 77.3 147* 705
(n = 50) (0.10, 0.61) (29.1, 31.9) (72.3, 84.9) (138, 156) (652, 747)
Group 2: 2.54 24.0 147* 358 1291
(n = 50) (2.15, 3.95) (24.0, 24.6) (138, 155) (259, 382) (1204, 1322)
Desethylamodiaquine (10 mg/kg of amodiaquine at 0, 24 and 48 h) Group 1: 9.67 24.0 147* 348 651
(n = 50) (7.03, 10.1) (24.0, 24.1) (129, 157) (339, 398) (599, 651)
Group 2: 0.71 24.0 98.0 147* 348
(n = 50) (0.38, 1.36) (24.0, 24.1) (88.4, 106) (129, 157) (316, 397)
  1. *3rd hour of the seventh day of treatment.