Malaria Journal

Table 1 Summary of the patient populations by treatment arm in the five clinical trials

From: Multiple treatment comparisons in a series of anti-malarial trials with an ordinal primary outcome and repeated treatment evaluations

						Day14			Day21				Day28
Study	Year	Treat	m ₁	m ₂	m ₃	ACPR	LPF	LCF	ACPR	LPF	LCF	NA	ACPR	LPF	LCF	NA
#
	2005	AQ	64	3	61	58	2	1	54	0	2	5	50	2	2	7
	Feb-May	ASAQ	60	3	57	56	0	1	49	0	4	4	43	3	3	8
1		ASSP	61	3	58	58	0	0	55	1	1	1	50	3	2	3
	Subtotal		185	9	176	172	2	2	158	1	7	10	143	8	7	18
	2006 1	AQSP	67	3	64	64	0	0	61	1	1	1	55	1	4	4
	Apr-Jul	ASMQ	69	8	61	61	0	0	61	0	0	0	60	1	0	0
2	Subtotal		136	11	125	125	0	0	122	1	1	1	115	2	4	4
	2006 2	ASAQ	62	4	58	58	0	0	52	4	1	1	52	0	0	6
	Sep-Nov	AMLM	61	1	60	60	0	0	58	2	0	0	58	0	0	2
3	Subtotal		123	5	118	118	0	0	110	6	1	1	110	0	0	8
	2006 3	ASCD	86	14	72	71	1	0	57	6	8	1	53	2	1	16
4	Dec-Feb	ASSP	82	1	81	81	0	0	79	0	2	0	74	2	2	3
	Subtotal		168	15	153	152	1	0	136	6	10	1	110	0	0	19
	2007	ASAQ	92	4	88	87	1	0	78	6	3	1	73	5	0	10
5	Apr-Jul	DHPP	91	5	86	86	0	0	86	0	0	0	84	2	0	0
	Subtotal		183	9	164	173	1	0	164	6	3	1	157	7	0	10
	Subtotal	ASAQ	214	11	203	201	1	1	179	10	8	6	168	8	3	24
		Others	581	38	543	539	3	1	513	10	14	8	484	13	11	35
	Total		795	49	746	740	4	2	690	20	22	14	652	21	14	59

m₁: number of included patients, m₂: number of drop-out and lost to follow-up before Day 14, m₃: number of evaluated patients on Day 14. ACPR adequate clinical and parasitological response, LPF late parasitological failure, LCF late clinical failure), NA: not available outcome. AQ, amodiaquine; SP, sulphadoxine-pyrimethamine; AS, artesunate; AM, artemether; DHPP, dihydroartemisinin-piperaquine; LM, lumefantrine; CD, chlorproguanil-dapsone.

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ISSN: 1475-2875

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