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Table 3 Histological analysis by treatment arm

From: Artemether-lumefantrine to treat malaria in pregnancy is associated with reduced placental haemozoin deposition compared to quinine in a randomized controlled trial

  

Quinine

AL

p

p-adjusted

Formalin pigment

n (%)

8/97 (8.2%)

8/98 (8.2%)

0.983

0.984

Haemozoin present

n (%)

60/89 (67.4%)

58/90 (64.4%)

0.675

0.954

Haemozoin (% of HPF)

Median [IQR]; n

3.3 [0-10.6]; 88

1.5 [0-5.7]; 90

0.090

0.101

Haemozoin >10% of HPF

n (%)

23/89 (25.8%)

12/90 (13.3%)

0.031

0.028

Inflammation

n (%)

8/97 (8.2%)

8/98 (8.2%)

0.999

0.974

Parasitized RBC

n (%)

5/89 (5.6%)

8/90 (8.9%)

0.566

0.241

  1. Adjusted p-values are corrected for day of enrolment, gravidity, parasitemia at enrolment and reinfection. AL- artemether-lumefantrine; HPF- high power fields.