Table 2 Haematology, blood chemistry and parasitology findings of study subjects on enrolment by the study drug
Parameter | Artemisinin- naphthoquine (AN) | Dihydroartemisinin- piperaquine (DHP) | P | Overall |
|---|---|---|---|---|
Number of subjects | 201 | 200 | Â | 401 |
Haematocrit: mean ± SD (range)% | 36.1 ± 7.1 (15.5–68.9) | 36.6 ± 6.6 (19.1–63.4) | 0.46 | 36.4 ± 6.8 (15.5–68.9) |
Haemoglobin: mean ± SD (range) g/dL | 12.5 ± 2.3 (6.2–23.1) | 12.6 ± 2.1 (6.6–21.1) | 0.67 | 12.6 ± 2.2 (6.2–23.1) |
Red Blood Cell: mean ± SD (range) per uL | 4.5 ± 0.8 (1.5–7.7) | 4.4 ± 0.8 (2.2–7.3) | 0.70 | 4.4 ± 0.8 (1.5–7.7) |
Platelet: mean ± SD (range) 10 3 /mm 3 | 116.4 ± 68.7 (1.8–381.0) | 116.5 ± 65.9 (1 .0–601.0) | 0.98 | 116 ± 67.2 (1.0–601.0) |
White Blood Cell: mean ± SD (range) per uL | 6.4 ± 2.2 (2.0–14.0) | 7.1 ± 6.0 (2.2–65.0) | 0.11 | 6.8 ± 4.5 (2.0–65.0) |
Bilirubin: mean ± SD (range) mg/dL | 1.0 ± 0.6 (0.1–5.2) | 1.0 ± 0.5 (0.1–3.8) | 0.67 | 1.0 ± 0.5 (0.1–5.2) |
Albumin: mean ± SD (range) g/dL | 4.1 ± 1.0 (2.0–7.4) | 4.2 ± 1.0 (2.2–6.2) | 0.25 | 4.2 ± 1.0 (2.1–7.4) |
ALT (SGPT): mean ± SD (range) IU/L | 28.8 ± 13.0 (5–73) | 28.3 ± 14.2 (6.9–98.0) | 0.71 | 28.5 ± 13.9 (5.0–98.0) |
AST (SGOT): mean ± SD (range) IU/L | 29.4 ± 14.0 (2.0–87.0) | 28.5 ± 11.8 (2.6–91.0) | 0.49 | 28.9 ± 12.9 (2.0–91.0) |
Creatinine: mean ± SD (range) mg/dL | 1.0 ± 0.4 (0.2–2.5) | 0.9 ± 0.3 (0.2–2.0) | 0.15 | 0.9 ± 0.4 (0.2–2.5) |
Urea: mean ± SD (range) mg/dL | 27.5 ± 11.7 (2.7–80.0) | 27.6 ± 11.7 (8.6–110.0) | 0.94 | 27.6 ± 11.7 (2.7–110.0) |
Density of asexual parasites: geometric mean (range) per uL | 6310 (304–113550) | 6972 (372–140084) | 0.21 | 6634 (304–140084) |
Gametocyte carriages (%) | 134 (67.3) | 140 (70.3) | 0.54 | 274 (68.8) |
Density of gametocytes: geometric mean (range) per uL | 40 (1–2697) | 35 (2–2208) | 0.55 | 38 (1–2697) |