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Table 3 PCR uncorrected efficacy of AN vs DHP in all malaria, Indonesia

From: Efficacy and safety of artemisinin-naphthoquine versus dihydroartemisinin-piperaquine in adult patients with uncomplicated malaria: a multi-centre study in Indonesia

Outcome Artemisinin- naphthoquine (AN) Dihydroartemisinin-piperaquine (DHP) P Overall
ACPR/Treatment Success (%, 95% CL)     
ITT 179 [89.1 (84.7–93.4)] 180 [90.0 (85.8–94.2)] 0.76 359 [89.5 (86.1–92.3)]
Modified ITT 179 [92.3 (88.5–96.0)] 180 [94.7 (91.6–97.9)] 0.33 359 [93.5 (90.5–95.7)]
Per Protocol 179 [93.7 (90.3–97.2)] 180 [96.3 (93.5–99.0)] 0.26 359 [95.0 (92.3–96.9)]
Late Clinical Failure-LCF (%, 95% CL)     
ITT 5 [2.5 (0.3–4.6)] 1 [0.5 (0.5–1.5)] 0.10 6 [1.5 (0.6–3.2)]
Modified ITT 5 [2.6 (0.3–4.8)] 1 [0.5 (0.5–1.6)] 0.10 6 [1.6 (0.6–3.4)]
Per Protocol 5 [2.6 (0.4–4.9)] 1 [0.5 (0.5–1.6)] 0.10 6 [1.6 (0.6–3.4)]
Late Parasitological Failure-LPF (%, 95% CL)     
ITT 7 [3.5 (0.9–6.0)] 6 [3.0 (0.6–5.4)] 0.78 13 [3.2 (1.7–5.5)]
Modified ITT 7 [3.6 (1.0–6.2)] 6 [3.2 (0.7–5.6)] 0.81 13 [3.4 (1.8–5.7)]
Per Protocol 7 [3.7 (1.0–6.3)] 6 [3.2 (0.7–5.7)] 0.81 13 [3.4 (1.8–5.8)]
“Other Failures” (%, 95% CL)     
ITT 10 [5.0 (2.0–8.0)] 13 [6.5 (3.1–9.9)] 0.51 23 [5.7 (3.7–8.5)]
Modified ITT 3 [1.5 (0.2–3.3)] 3 [1.6 (0.2–3.4)] 0.98 6 [1.6 (0.6–3.4)]
Per Protocol 0 0   0
  1. All protocol violations, withdrawn consents, and lost to follow up were classified as “other failures” in ITT analysis.
  2. All protocol violations and withdrawn consents were classified as “other failures” in modified ITT analysis.