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Table 3 PCR uncorrected efficacy of AN vs DHP in all malaria, Indonesia

From: Efficacy and safety of artemisinin-naphthoquine versus dihydroartemisinin-piperaquine in adult patients with uncomplicated malaria: a multi-centre study in Indonesia

Outcome

Artemisinin- naphthoquine (AN)

Dihydroartemisinin-piperaquine (DHP)

P

Overall

ACPR/Treatment Success (%, 95% CL)

    

ITT

179 [89.1 (84.7–93.4)]

180 [90.0 (85.8–94.2)]

0.76

359 [89.5 (86.1–92.3)]

Modified ITT

179 [92.3 (88.5–96.0)]

180 [94.7 (91.6–97.9)]

0.33

359 [93.5 (90.5–95.7)]

Per Protocol

179 [93.7 (90.3–97.2)]

180 [96.3 (93.5–99.0)]

0.26

359 [95.0 (92.3–96.9)]

Late Clinical Failure-LCF (%, 95% CL)

    

ITT

5 [2.5 (0.3–4.6)]

1 [0.5 (0.5–1.5)]

0.10

6 [1.5 (0.6–3.2)]

Modified ITT

5 [2.6 (0.3–4.8)]

1 [0.5 (0.5–1.6)]

0.10

6 [1.6 (0.6–3.4)]

Per Protocol

5 [2.6 (0.4–4.9)]

1 [0.5 (0.5–1.6)]

0.10

6 [1.6 (0.6–3.4)]

Late Parasitological Failure-LPF (%, 95% CL)

    

ITT

7 [3.5 (0.9–6.0)]

6 [3.0 (0.6–5.4)]

0.78

13 [3.2 (1.7–5.5)]

Modified ITT

7 [3.6 (1.0–6.2)]

6 [3.2 (0.7–5.6)]

0.81

13 [3.4 (1.8–5.7)]

Per Protocol

7 [3.7 (1.0–6.3)]

6 [3.2 (0.7–5.7)]

0.81

13 [3.4 (1.8–5.8)]

“Other Failures” (%, 95% CL)

    

ITT

10 [5.0 (2.0–8.0)]

13 [6.5 (3.1–9.9)]

0.51

23 [5.7 (3.7–8.5)]

Modified ITT

3 [1.5 (0.2–3.3)]

3 [1.6 (0.2–3.4)]

0.98

6 [1.6 (0.6–3.4)]

Per Protocol

0

0

 

0

  1. All protocol violations, withdrawn consents, and lost to follow up were classified as “other failures” in ITT analysis.
  2. All protocol violations and withdrawn consents were classified as “other failures” in modified ITT analysis.