Table 2 Distribution of pfcrt haplotypes, pfmdr-1 N86Y mutation and (pfcrt-pfmdr-1) 2 loci mutation i.e. combined genotype
| Â | no. of isolates (%) in high P.falciparum prevalent areas | Â | no. of isolates (%) in low P.falciparum prevalent areas | Â | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
pfcrt haplotype a | Assam | Orissa | Jharkhand | West Bengal | Chhattisgarh | Maharastra | total | Gujarat | Goa | Tamil Nadu | Rajasthan | Uttar Pradesh | total |
CVMNK-A | 0 | 11(20.37) | 7(20.58) | 0 | 11(68.75) | 5(35.72) | 34(21.25) | 0 | 0 | 0 | 1(3.85) | 0 | 1(0.78) |
CVIET-S | 15(57.69) | 17(31.48) | 20(58.82) | 4(25) | 0 | 0 | 56 (35) | 0 | 1(3.85) | 0 | 0 | 0 | 1(0.78) |
S VMNT-S | 11(42.30) | 25(46.29) | 6(17.64) | 12(75) | 4(25) | 9(64.28) | 67(41.87) | 33(100) | 25(96.15) | 25(100) | 25(96.25) | 17(100) | 125(98.42) |
CVMDT-S | 0 | 0 | 1(2.94) | 0 | 0 | 0 | 1(0.62) | 0 | 0 | 0 | 0 | 0 | 0 |
CVMNK-S | 0 | 0 | 0 | 0 | 1(6.25) | 0 | 1(0.62) | 0 | 0 | 0 | 0 | 0 | 0 |
S VMNT-A | 0 | 1(1.85) | 0 | 0 | 0 | 0 | 1(0.62) | 0 | 0 | 0 | 0 | 0 | 0 |
pfmdr mutation b | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
N86 wt | 6(24) | 28(51.85) | 18(52.94) | 12(75) | 13(81.25) | 14(100) | 91(57.23) | 32(96.96) | 26(100) | 24(96) | 21(80.76) | 17(100) | 120(94.48) |
N86Y mt | 19(76) | 26(48.14) | 16(47.05) | 4(25) | 3(18.75) | 0 | 68(42.76) | 1(3.03) | Â | 1(4) | 5(19.23) | Â | 7(5.51) |
Combined genotype a | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
CVIETS -N | 3(12) | 8(14.81) | 11(32.35) | 0 | 0 | 0 | 22(13.83) | 0 | 1(3.85) | 0 | 0 | 0 | 1(0.78) |
CVIETS -Y | 12(48) | 9(16.66) | 9(26.47) | 4(25) | 0 | 0 | 34(21.38) | 0 | 0 | 0 | 0 | 0 | 0 |
S VMNT A -N | 0 | 1(1.8) | 0 | 0 | 0 | 0 | 1(0.62) | 0 | 0 | 0 | 0 | 0 | 0 |
S VMNTS -N | 3(12) | 10(18.51) | 1(2.9) | 12(75) | 1(6.25) | 9(64.28) | 36(22.64) | 32(96.96) | 25(96.15) | 24(96) | 20(76.92) | 17(100) | 118(92.91) |
S VMNTS-Y | 7(28) | 15(27.77) | 5(14.7) | 0 | 3(18.75) | 0 | 30(18.86) | 1(3.03) | 0 | 1(4) | 5(19.23) | 0 | 7(5.51) |
CVMNKA-N | 0 | 9(16.66) | 7(20.58) | 0 | 11(68.75) | 5(35.71) | 32(20.12) | 0 | 0 | 0 | 1(3.85) | 0 | 1(0.78) |
CVMNKA-Y | 0 | 2(3.7) | 0 | 0 | 0 | 0 | 2(1.25) | 0 | 0 | 0 | 0 | 0 | 0 |
CVMDTS -Y | 0 | 0 | 1(2.9) | 0 | 0 | 0 | 1(0.62) | 0 | 0 | 0 | 0 | 0 | 0 |
CVMNKS -N | 0 | 0 | 0 | 0 | 1(6.25) | 0 | 1(0.62) | 0 | 0 | 0 | 0 | 0 | 0 |