Figure 4

Pc AS-infected mice contain less total Hz than Plasmodium berghei -infected mice. The total amount of Hz (nmol haematin)/mouse was estimated from the sum of the Hz content in the individual organs. Panel A shows the average amount of Hz found in C57BL/6 J mice infected with Pb ANKA, Pb NK65 or Pc AS on different time points post-infection, with the contribution of each organ to the total amount of Hz ± SEM. Asterisks on top of data sets indicate the statistical significances compared with the uninfected control group. Horizontal lines with asterisks on top indicate statistical differences between infected groups. * p < 0.05, ** p < 0.01 and *** p < 0.001. In panel B, the total amount of Hz (nmol haematin) was correlated with the level of parasitaemia (%) for each parasite strain separately and the individual regression lines are shown. The regression line of Pb ANKA was prolonged under the form of a hatched line to better distinguish it from the Pb NK65 line. The equation of the regression lines and the R²-values, together with Spearman r-values and p-values are shown in panel C