Toll-like receptor 9 (TLR9) polymorphism associated with symptomatic malaria: a cohort study

Malaria Journal

Table 1 The strength of pairwise linkage disequilibrium for the four TLR9 SNPs analysed in the study

r² D¹	rs352140	rs352139	rs5743836	rs187084
rs352140		0.237	0.032	0.175
rs352139	1.0		0.319	0.277
rs5743836	0.4	0.857		0.014
rs187084	0.535	0.846	0.124

D¹ is the measure for deviation of the observed haplotype frequency from the expected frequency, with D¹ =1 showing that the examined loci are completely dependent on one another. r² is the correlation coefficient between pair of two loci and r² > 0.4 showing a meaningful association while r² > 0.2 being suggestive.

ISSN: 1475-2875