Toll-like receptor 9 (TLR9) polymorphism associated with symptomatic malaria: a cohort study

Malaria Journal

Table 2 Incidence, relative risk and attributable risk of mild malaria among carriers of TLR9 SNP’s genotypes

^aSNPs	Incidence	Relative risk	Attributable risk	^bCI	p value	^cp_c
rs187084 (C-1486 T)
TT vs. CC + TC	0.04	0.37	−0.061	(−0.11)-(−0.01)	0.01	ns
CC vs. TT + TC	0.20	3.7	0.144	0.03-0.26	0.01	ns
rs5743836 (C-1237 T)
TT vs. CC + TC	0.04	0.38	−0.060	(−0.11)-(−0.01)	0.01	ns
CC vs. TT + TC	0.09	1.29	0.020	(−0.05)-(0.09)	0.6	ns
rs352139 (G + 1174A)
GG vs. AA + GA	0.15	4.8	0.116	0.05-0.18	0.0003	0.0024
AA vs. GG + GA	0.03	0.3	−0.055	(−0.10)-(−0.01)	0.03	ns
rs352140 (G + 2848A)
GG vs. AA + GA	0.04	0.3	−0.076	(−0.13)-(−0.02)	0.006	0.048
AA vs. GG + GA	0.11	1.63	0.044	(−0.08)-(0.17)	0.5	ns

^aSNPs: Single nucleotide polymorphisms; ^bCl: confidence intervals; ^cp_c = corrected p value by bonferroni method by factor of 8; ns: not statistically significant. The incidence shown is for the genotype highlighted in bold, the relative and attributable risk shown are for the same genotype when compared with the non-carriers of the genotype. Corrected p value <0.05 was considered to be statistically significant.

ISSN: 1475-2875