Toll-like receptor 9 (TLR9) polymorphism associated with symptomatic malaria: a cohort study

Malaria Journal

Table 3 Incidence, relative risk and attributable risk of mild malaria among carriers of TLR9 haplotypes

^aHaplotype	Incidence	Relative risk	Attributable risk	^bCI	p value	^c p _c
TTAG vs. non-TTAG	0.03	0.2	−0.115	(−0.16)-(−0.07)	8x10 ^-7	4x10 ^-6
CTGA vs. non-CTGA	0.15	3.3	0.103	0.04-0.16	0.001	0.005
TCGG vs. non TCGG	0.10	1.5	0.032	(−0.03)-(0.09)	0.3	ns
CCGG vs. non-CCGG	0.12	2.1	0.063	0.0-0.1	0.05	ns
TCGA vs. non-TCGA	0.09	1.2	0.012	(−0.07)-(0.09)	0.8	ns

^aHaplotype for rs187084 (C-1486 T), rs5743836 (C-1237 T), rs352139 (G + 1174A) and rs352140 (G + 2848A), respectively; ^bCl: confidence intervals; ^cp_c = corrected p value by Bonferroni’s method by a factor of 5; ns: not statistically significant. The incidence shown is for the haplotype highlighted in bold, the relative and attributable risk shown are for the same haplotype when compared with the non-carriers of the haplotype. Corrected p value <0.05 was considered to be statistically significant.

ISSN: 1475-2875