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Table 1 50% Inhibition concentrations (IC 50) (ng/mL) of lumefantrine, atovaquone and chloroquine under different culture conditions: using medium supplemented with 10% serum obtained from a fasting donor (‘fasting’) or obtained 2 hours after ingestion of a fatty meal (‘2hours’)

From: The effects of serum lipids on the in vitro activity of lumefantrine and atovaquone against Plasmodium falciparum

Drug

Serum used in culture medium

IC 50 (ng/mL)(Mean ± SD)

Lumefantrine

fasting

191 ± 53

2 hours

465 ± 34*

Atovaquone

fasting

0.5 ± 0.3

2 hours

12 ± 6*

Chloroquine

fasting

94 ± 39

2 hours

94 ± 14

  1. Data of three replicate measurements of the same parasites (N = 10)
  2. * P<0.005 when compared to fasting.