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Table 2 IgG antibody responses to infected erythrocytes surface antigens

From: Low antibodies against Plasmodium falciparum and imbalanced pro-inflammatory cytokines are associated with severe malaria in Mozambican children: a case–control study

Parasitesa Seroprevalenceb(N = 67 pairs) IgG levelsc(N = 67 pairs)
SM UM Matched comparison P SM UM Matched comparison P
R29 64 (96) 65 (97) 5 (7) 1.000 11.5 (8.7, 18.2) 9.9 (6.6, 20.2) 2.0 (−8.6, 9.1) 0.088
FCR3CSA 8 (12) 11 (16) 15 (22) 0.608 7.6 (6.6, 9.3) 7.7 (6.7, 9.2) −0.3 (−2.3, 1.6) 0.609
E8BCD36 58 (87) 62 (93) 14 (21) 0.414 6.7 (4.2, 11.3) 6.9 (4.5, 10.7) −0.8 (−4.3, 4.5) 0.636
ITGICAM1 11 (16) 15 (22) 24 (36) 0.300 1.1 (0.1, 2.1) 1.3 (0.2, 2.5) −0.4 (−2.5, 1.6) 0.345
MOZ1 17 (25) 18 (27) 25 (37) 0.666 28.0 (23.6, 31.8) 26.9 (24.5, 33.9) 0.01 (−5.5, 4.9) 1.000
MOZ2 40 (60) 36 (54) 34 (51) 0.367 1.8 (0.8, 5.9) 1.6 (0.8, 4.8) 0.7 (−2.3, 3.8) 0.334
MOZ3 32 (48) 30 (45) 34 (51) 0.611 2.6 (1.6, 4.1) 2.4 (1.3, 4.9) 0.2 (−2.3, 2.3) 0.650
MOZ4 47 (70) 44 (66) 27 (40) 0.704 5.3 (−1.4, 24.9) 3.3 (−1.4, 13.1) 2.8 (−11.9, 19.1) 0.329
MOZ5 51 (76) 56 (83) 24 (36) 0.293 88.0 (53.1, 115.4) 83.4 (62.3, 129.9) −7.4 (−45.7, 35.6) 0.727
PLC1 0 (0) 3 (4) 3 (4) 0.255 58.3 (53.2, 64.8) 60.7 (51.9, 67.5) −1.1 (−8.7, 7.3) 0.547
PLC2 0 (0) 3 (4) 3 (4) 0.255 19.8 (12.3, 24.2) 18.6 (10.1, 24.5) −0.7 (−8.2, 8.9) 0.907
  1. a MOZ, isolates from Mozambican children; PLC, placental isolates from Mozambican women.
  2. b Presented as the number (%) of responders. Matched comparison reports the number (%) of divergent pairs. P- values calculated using McNemar’s test. Thresholds for seroprevalence (MFI): R29 = 5.1, FCR3CSA = 10.1, E8BCD36 = 2.6, ITGICAM = 2.7, MOZ1 = 31.7, MOZ2 = 1.4, MOZ3 = 2.9, MOZ4 = 0.4, MOZ5 = 52.6, PLC1 = 107.6, PLC2 = 42.9.
  3. c Presented as medians (inter-quartile range) of MFI values. Matched comparison reports the median difference (inter-quartile range) of IgG levels between SM and UM. P- values calculated using Sign test.
  4. All comparisons were corrected by the Monte Carlo permutation test (1000 random permutations).