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Table 2 IgG antibody responses to infected erythrocytes surface antigens

From: Low antibodies against Plasmodium falciparum and imbalanced pro-inflammatory cytokines are associated with severe malaria in Mozambican children: a case–control study

Parasitesa

Seroprevalenceb(N = 67 pairs)

IgG levelsc(N = 67 pairs)

SM

UM

Matched comparison

P

SM

UM

Matched comparison

P

R29

64 (96)

65 (97)

5 (7)

1.000

11.5 (8.7, 18.2)

9.9 (6.6, 20.2)

2.0 (−8.6, 9.1)

0.088

FCR3CSA

8 (12)

11 (16)

15 (22)

0.608

7.6 (6.6, 9.3)

7.7 (6.7, 9.2)

−0.3 (−2.3, 1.6)

0.609

E8BCD36

58 (87)

62 (93)

14 (21)

0.414

6.7 (4.2, 11.3)

6.9 (4.5, 10.7)

−0.8 (−4.3, 4.5)

0.636

ITGICAM1

11 (16)

15 (22)

24 (36)

0.300

1.1 (0.1, 2.1)

1.3 (0.2, 2.5)

−0.4 (−2.5, 1.6)

0.345

MOZ1

17 (25)

18 (27)

25 (37)

0.666

28.0 (23.6, 31.8)

26.9 (24.5, 33.9)

0.01 (−5.5, 4.9)

1.000

MOZ2

40 (60)

36 (54)

34 (51)

0.367

1.8 (0.8, 5.9)

1.6 (0.8, 4.8)

0.7 (−2.3, 3.8)

0.334

MOZ3

32 (48)

30 (45)

34 (51)

0.611

2.6 (1.6, 4.1)

2.4 (1.3, 4.9)

0.2 (−2.3, 2.3)

0.650

MOZ4

47 (70)

44 (66)

27 (40)

0.704

5.3 (−1.4, 24.9)

3.3 (−1.4, 13.1)

2.8 (−11.9, 19.1)

0.329

MOZ5

51 (76)

56 (83)

24 (36)

0.293

88.0 (53.1, 115.4)

83.4 (62.3, 129.9)

−7.4 (−45.7, 35.6)

0.727

PLC1

0 (0)

3 (4)

3 (4)

0.255

58.3 (53.2, 64.8)

60.7 (51.9, 67.5)

−1.1 (−8.7, 7.3)

0.547

PLC2

0 (0)

3 (4)

3 (4)

0.255

19.8 (12.3, 24.2)

18.6 (10.1, 24.5)

−0.7 (−8.2, 8.9)

0.907

  1. a MOZ, isolates from Mozambican children; PLC, placental isolates from Mozambican women.
  2. b Presented as the number (%) of responders. Matched comparison reports the number (%) of divergent pairs. P- values calculated using McNemar’s test. Thresholds for seroprevalence (MFI): R29 = 5.1, FCR3CSA = 10.1, E8BCD36 = 2.6, ITGICAM = 2.7, MOZ1 = 31.7, MOZ2 = 1.4, MOZ3 = 2.9, MOZ4 = 0.4, MOZ5 = 52.6, PLC1 = 107.6, PLC2 = 42.9.
  3. c Presented as medians (inter-quartile range) of MFI values. Matched comparison reports the median difference (inter-quartile range) of IgG levels between SM and UM. P- values calculated using Sign test.
  4. All comparisons were corrected by the Monte Carlo permutation test (1000 random permutations).