Variables | Age groups | ||
---|---|---|---|
 | All (n = 549) | Children (age ≤ 15 yrs) (n = 357) | Adults (age > 15 yrs) (n = 192) |
42-day cure rate, no. (%) of patients a | 532/549 (97) | 342/357 (96)* | 190/192 (99) |
42-day cure rate per protocol, no. (%) of patientsΨ | 524/541 (97) | 337/352 (96)* | 187/189 (99) |
Fever clearance time, mean hours (95%CI)a,b | 25.3 (23.9-26.8) | 27.6 (25.7 – 29.5)* | 21.2 (19.2 – 23.2) |
Patients remained febrile at day 1, no. (%) | 241 (44) | 169 (47)* | 72 (37.5) |
Patients remained febrile at day 2, no. (%) | 33 (6) | 29 (8)* | 4 (2) |
Parasite clearance time, median days (range)a,c | 1 (1 - 3) | 1 (1 - 2)* | 1 (1 - 3) |
Positive parasitaemia at day 1, no. (%) of patients | 144/548 (26) | 116/356 (33)* | 28/192 (15) |
Positive parasitaemia at day 2, no. (%) of patients | 1 | 0 | 1 |
Gametocytaemia detected at anytime, no.(%) of patients | 27 (5) | 23 (6) | 4 (2) |
Gametocytaemia after treatment, no. (%) of patients | 4 (0.73) | 4 (1.12) | 0 |
Gametocyte clearance time, median days (range) d | 7 (1 – 21) | 3 (1 -21) | 7 (7 – 14) |
Gametocyte cleared by day 7, no. (%) d | 24 (89) | 21 (91) | 3 (75) |
Median (range) gametocyte-person-weeks d | 0.42 (0.14 – 1.0) | 0.42 (0.14 – 1.0) | 0.42 (0.42 – 0.42) |
P. vivax appearance after treatment for P. falciparum, no. (%) of patients | 18/594 (3) | 17/357 (5)* | 1/192 (0.5) |
Day 0 haematocrit, mean % (95%CI) | 35.8(35.2 – 36.3) | 33.7 (33.1 – 34.4)* | 39.5 (38.7 – 40.4) |
Day 1 haematocrit, mean % (95%CI) | 32.4 (31.9 – 32.9) | 30.4 (29.8 – 30.9)* | 36.2 (35.4 – 36.9) |
Day 2 haematocrit, mean % (95%CI) | 31.1 (30.6 – 31.6) | 29.1 (28.5 – 29.6)* | 34.9 (34.1 – 35.7) |
Day 3 haematocrit, mean % (95%CI) | 31.1 (30.6 – 31.6) | 29.0 (28.5 – 29.6)* | 34.9 (34.1 – 35.6) |
Day 7 haematocrit, mean % (95%CI) | 33.3 (32.9 – 33.7) | 31.7 (31.2 – 32.1)* | 36.3 (35.6 – 37.0) |
Day 14 haematocrit, mean % (95%CI) | 34.4 (34.0 – 34.8) | 33.3 (32.9 – 33.7)* | 36.5 (35.8 – 37.2) |
Day 21 haematocrit, mean % (95%CI) | 35.6 (35.2 – 35.9) | 34.6 (34.2 – 35.0)* | 37.5 (36.8 – 38.2) |
Day 28 haematocrit, mean % (95%CI) | 36.2 (35.8 – 36.5) | 35.3 (34.9 – 35.7)* | 37.8 (37.0 – 38.5) |
Day 35 haematocrit, mean % (95%CI) | 36.5 (36.1 – 36.8) | 35.5 (35.2 – 35.9)* | 38.2 (37.5 – 38.9) |
Day 42 haematocrit, mean % (95%CI) | 37.6 (37.2 – 37.9) | 36.7 (36.3 – 37.0)* | 39.4 (38.7 – 40.1) |