Role of polymorphisms of toll-like receptor (TLR) 4, TLR9, toll-interleukin 1 receptor domain containing adaptor protein (TIRAP) and FCGR2A genes in malaria susceptibility and severity in Burundian children

Table 1 Allele frequencies in the study population for the selected SNPs

Gene and polymorphic alleles	Allele frequency
Gene and polymorphic alleles	Uninfected controls (n = 337)	Children with malaria (n = 602)	P value	Children with uncomplicated malaria (n = 553)	Children with severe malaria (n = 49)	P value
TLR4 Asp299Gly rs4986790
Asp	0.94	0.94		0.93	0.98
Gly	0.06	0.06	0.55	0.07	0.02	0.07
TLR9 G1174A rs352139
G	0.51	0.53		0.52	0.57
A	0.49	0.47	0.61	0.48	0.43	0.36
TLR9 T1486C rs187084
T	0.75	0.75		0.76	0.72
C	0.25	0.25	0.94	0.24	0.28	0.45
TLR9 T1237C rs5743836*
T	0.68	0.63		0.63	0.63
C	0.32	0.37	0.04	0.36	0.37	0.93
TIRAP Ser180Leu rs8177374
Ser	0.98	0.97		0.97	0.98
Leu	0.02	0.03	0.50	0.03	0.02	0.59
FCGR2a H131R rs1801274
His	0.45	0.43		0.42	0.45
Arg	0.55	0.57	0.58	0.58	0.55	0.61

Significant difference between uninfected controls and children with malaria for TLR9 T1237C rs5743836 only. No difference between children with uncomplicated malaria and those with severe malaria.

ISSN: 1475-2875