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Table 1 Tolerability and effectiveness of different treatment regimens in 504 malaria-patients in Europe

From: Therapy of uncomplicated falciparum malaria in Europe: MALTHER – a prospective observational multicentre study

 

Total

AQ + PG*

MQ*

AR + LU*

QUI*

AR + MQ*

QUI + CL*

QUI + TC*

QUI + AQPG*

Other*

Overall test

p-Value

N = 504

N = 253

N = 97

N = 39

N = 33

N = 20

N = 20

N = 16

N = 15

N = 11

Treatment change, N (%)

          

0.0053a

· no change

451 (89.5)

223 (88.1)

92 (94.9)

37 (94.9)

25 (75.8)

19 (95.0)

17 (85.0)

13 (81.3)

15 (100.0)

10 (90.9)

 

· due to progress of severity§

2 (0.4)

2 (0.8)

0 (0.0)

0 (0.0)

0 (0.0)

0 (0.0)

0 (0.0)

0 (0.0)

0 (0.0)

0 (0.0)

 

· due to AE other than vomiting

10 (2.0)

2 (0.8)

0 (0.0)

1 (2.6)

5 (15.2)

1 (5.0)

1 (5.0)

0 (0.0)

0 (0.0)

0 (0.0)

 

· due to vomiting

30 (6.0)

22 (8.7)

5 (5.2)

0 (0.0)

0 (0.0)

0 (0.0)

0 (0.0)

3 (18.8)

0 (0.0)

0 (0.0)

 

· due to other reasons

11 (2.2)

4 (1.6)

0 (0.0)

1 (2.6)

3 (9.1)

0 (0.0)

2 (10.0)

0 (0.0)

0 (0.0)

1 (9.1)

 

Pts. with any AE $ , N (%)

82 (16.3)

34 (13.4)

22 (22.7)

1 (2.6)

12 (36.4)

2 (10.0)

7 (35.0)

2 (12.5)

2 (13.3)

0 (0.0)

0.0009 a

Parasite clearance time

72

72

54

72

48

36

48

48

72

48

<0.0001b

Hour median (min-max)

(0-168)

(0-168)

(2-168)

(24-168)

(24-96)

(12-96)

(24-96)

(24-108)

(24-168)

(0-96)

Fever clearance time,

48

48

24

48

24

16

48

72

48

36

<0.0001b

Hour median (min-max)

(0-192)

(0-192)

(0-168)

(0-72)

(0-144)

(0-80)

(24-96)

(24-96)

(0-168)

(4-60)

Duration of hospitalization #

4

4

4

4

6

3.5

5

5

3.5

4

0.0002 b

Day median (min-max)

(1-18)

(2-15)

(1-18)

(2-7)

(1-13)

(1-18)

(3-7)

(3-8)

(3-7)

(1-7)

Cure rate at day 28 &

372/376

191/194

73/73

97.0

25/25

9/9

11/11

10/10

13/13

8/8

0.7371a

N cured/N followed-up (%)

(98.9)

(98.5)

(100.0)

(33)

(100.0)

(100.0)

(100.0)

(100.0)

(100.0)

(100.0)

 
  1. a : Monte Carlo estimate for the exact chi-square test (1000000 samples); b : Kruskal-Wallis Test.
  2. Figures in bold italics indicate Bonferroni-Holm adjusted p-values <0.05 in against all other comparison.
  3. * : see additional file 1.
  4. § : according to the WHO 2000 severity criterion.
  5. $ : includes possible, mild adverse events.
  6. # : N = 401 (95 non hospitalized patients and 8 with missing data).
  7. & : complete case analysis (128 patients lost to follow-up not included in cure rate calculation; numbers of patients with follow-up data are given in the denominators of the cure rate).
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Malaria Journal

ISSN: 1475-2875

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