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Table 2 Characteristics of the major clinical phenotypes

From: Severe and uncomplicated falciparum malaria in children from three regions and three ethnic groups in Cameroon: prospective study

Parameter N CM N SMA N UM N RD P-value
Hyperpyrexia, n (%) 47 9 (19.1) 191 24 (12.6) 154 29 (18.8) 32 9 (28.1) 0.110
Hyperparasitaemia, n (%) 48 6 (12.5) 231 5 (2.2) 228 14 (6.1) 26 3 (11.5) 0.008
Hypoglycaemia, n (%) 49 - 187 24 (12.8) 177 18 (10.2) 26 4 (15.4) 0.617
Fatality, n (%) 47 11 (23.4) 187 11 (5.4) 154 3 (1.9) 33 5 (15.2) <0.001
Mean age ± SD (months) 49 37.85 ± 30.15 205 29.96 ± 27.33 201 51.41 ± 38.81 33 40.28 ± 34.33 <0.001
Mean haemoglobin ± SD (g/dl) 49 6.29 ± 2.34 225 3.65 ± 0.83 222 9.60 ± 1.31 31 7.71 ± 2.27 <0.001
*GMPD, parasites/μL 48 8,578 231 7,754 228 6,791 26 17,512 0.346
Mean spleen size ± SD (cm) 41 0.95 ± 1.66 124 1.51 ± 2.37 104 1.08 ± 1.94 15 3.13 ± 3.04§ 0.004
Mean plasma glucose ± SD (mmol/l) 49 6.41 ± 3.57 187 5.91 ± 4.41 177 6.23 ± 6.33 26 4.63 ± 4.25 0.474
  1. Age significantly higher than the corresponding values for SMA (P < 0.001) and CM (P = 0.050).
  2. §Spleen size significantly higher than the corresponding values for CM (P = 0.005), SMA (P = 0.033) and UM (P = 0.004).
  3. The haemoglobin values are significantly different between all four clinical groups; each participant has been categorised into one group only which clinicians felt was the primary phenotype. Samples numbers in some of the clinical groups are lower because some parameter estimates were not taken.