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Figure 7 | Malaria Journal

Figure 7

From: Erythropoietin treatment alleviates ultrastructural myelin changes induced by murine cerebral malaria

Figure 7

CM induces changes to the endothelium and blood–brain barrier in the CC. In uninfected mice regardless of treatment, the endothelium had a smooth appearance (A (UninfSal) and B (UninfEPO)). Vessel lumen denoted by V in A and B. In contrast, the endothelium of terminal ill CM mice had pseudopodic protrusions (arrows C and D) and often leukocyte adherence was noted (L in C). In some vessels the tight junctions were compromised and the astrocytic end feet did not support the endothelium (asterisk in D). Moreover, intracerebral haemorrhages into the CC were noted (E) and perivascular oedemas were frequent (O in F). In InfEPO mice, the endothelium had a normal appearance (G) and the tight junctions were intact (arrow heads in H). Scale bars correspond to 5 μm in A, 2 μm in D, E and G, to 1 μm in B, C and F and to 500 nm in H.

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