Table 2 Treatment outcomes as per-protocol after two-day course of artemisinin-piperaquine [ARPQ, children (n = 30), adults (n = 25)] and a three-day course of artesunate-amodiaquine [ASAQ, children (n = 31), adults (n = 28)] in Vietnamese patients with Plasmodium falciparum malaria
ARPQ | ASAQ | P value | ||
|---|---|---|---|---|
Parasite clearance time, median h (IQR) | ||||
All patients | 48 (12–72) | 36 (24–72) | <0.001 | |
Children | 48 (24–72) | 36 (24–72) | <0.001 | |
Adults | 36 (12–60) | 24 (24–48) | <0.001 | |
Fever clearance time, median h (IQR) | ||||
All patients | 24 (12–48) | 12 (12–48) | 0.07 | |
Children | 24 (12–48) | 12 (12–48) | 0.06 | |
Adults | 12 (12–24) | 12 (12–48) | 0.91 | |
Recrudescence within 42 days, n/N (%) | 1/55 (1.8%) | 1/59 (1.7%) | 0.51 | |
Reinfection within 28 days, n/N (%) | 0/55 (0%) | 2/59 (3.4%) | 0.51 | |
Reinfection within 42 days, n/N (%) | 7/55 (12.7%)a, b | 9/59 (15.3%)b | 0.91 | |