Table 2 Overall sensitivity, specificity, PPV and NPV of malaria diagnostic methods with expert microscopy as gold standard, stratified by age categories
From: Accuracy of malaria rapid diagnosis test Optimal-IT® in Kinshasa, the Democratic Republic of Congo
Sensitivity % (95% CI) | Specificity % (95% CI) | PPV % (95% CI) | NPV % (95% CI) | |
|---|---|---|---|---|
All age groups | ||||
History of fever | 82.9 (76.1-89.6) | 45.9 (41.5-50.2) | 27.3 (22.8-31.8) | 91.6 (88.2-95.0) |
Health centre microscopy | 86.2 (79.9-92.3) | 49.1 (44.7-53.4) | 29.4 (24.6-34.0) | 93.5 (90.5-96.5) |
Optimal-IT® | 79.7 (72.4-86.8) | 97.0 (95.5-98.5) | 86.7 (80.4-93.0) | 95.1 (93.2-97.0) |
Paracheck-Pf® | 87.8 (81.9-93.6) | 91.6 (89.1-94.0) | 72.0 (64.7-79.2) | 96.8 (95.2-98.4) |
Patients < 5 years | ||||
History of fever | 97.0 (90.7-100) | 11.7 (5.3-19.9) | 26.0 (18.1-33.8) | 92.3 (77.0-100) |
Health centre microscopy | 90.9 (80.5-100) | 47.6 (37.7-57.4) | 35.7 (25.3-46.1) | 94.2 (87.8-100) |
Optimal-IT® | 87.9 (76.1-99.6) | 97.0 (93.7-100) | 90.6 (80.2-100) | 96.2 (92.4-100) |
Paracheck-Pf® | 90.9 (80.5-101.2) | 94.2 (89.6-98.7) | 83.3 (70.9-95.8) | 97.0 (93.6-100) |
Patients > 5 years | ||||
History of fever | 77.8 (69.0-86.5) | 54.8 (49.8-59.7) | 28.0 (22.4-33.6) | 91.6 (88.0-95.1) |
Health centre microscopy | 84.4 (76.8-92.0) | 49.5 (44.5-54.4) | 27.4 (22.1-32.7) | 93.4 (90.0-96.7) |
Optimal-IT® | 76.7 (67.7-85.5) | 97.0 (95.2-98.6) | 85.2 (77.3-93.0) | 94.8 (92.7-97.0) |
Paracheck-Pf® | 86.7 (79.5-93.8) | 91.0 (88.1-93.7) | 68.4 (59.8-77.0) | 96.8 (95.0-98.6) |