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Table 2 Overall sensitivity, specificity, PPV and NPV of malaria diagnostic methods with expert microscopy as gold standard, stratified by age categories

From: Accuracy of malaria rapid diagnosis test Optimal-IT® in Kinshasa, the Democratic Republic of Congo

  Sensitivity % (95% CI) Specificity % (95% CI) PPV % (95% CI) NPV % (95% CI)
All age groups
History of fever 82.9 (76.1-89.6) 45.9 (41.5-50.2) 27.3 (22.8-31.8) 91.6 (88.2-95.0)
Health centre microscopy 86.2 (79.9-92.3) 49.1 (44.7-53.4) 29.4 (24.6-34.0) 93.5 (90.5-96.5)
Optimal-IT® 79.7 (72.4-86.8) 97.0 (95.5-98.5) 86.7 (80.4-93.0) 95.1 (93.2-97.0)
Paracheck-Pf® 87.8 (81.9-93.6) 91.6 (89.1-94.0) 72.0 (64.7-79.2) 96.8 (95.2-98.4)
Patients < 5 years
History of fever 97.0 (90.7-100) 11.7 (5.3-19.9) 26.0 (18.1-33.8) 92.3 (77.0-100)
Health centre microscopy 90.9 (80.5-100) 47.6 (37.7-57.4) 35.7 (25.3-46.1) 94.2 (87.8-100)
Optimal-IT® 87.9 (76.1-99.6) 97.0 (93.7-100) 90.6 (80.2-100) 96.2 (92.4-100)
Paracheck-Pf® 90.9 (80.5-101.2) 94.2 (89.6-98.7) 83.3 (70.9-95.8) 97.0 (93.6-100)
Patients > 5 years
History of fever 77.8 (69.0-86.5) 54.8 (49.8-59.7) 28.0 (22.4-33.6) 91.6 (88.0-95.1)
Health centre microscopy 84.4 (76.8-92.0) 49.5 (44.5-54.4) 27.4 (22.1-32.7) 93.4 (90.0-96.7)
Optimal-IT® 76.7 (67.7-85.5) 97.0 (95.2-98.6) 85.2 (77.3-93.0) 94.8 (92.7-97.0)
Paracheck-Pf® 86.7 (79.5-93.8) 91.0 (88.1-93.7) 68.4 (59.8-77.0) 96.8 (95.0-98.6)
  1. PPV = Positive Predictive Value, NPV = Negative Predictive Value, 95% CI = 95% Confidence Interval.