Two functional reticulocyte binding-like (RBL) invasion ligands of zoonotic Plasmodium knowlesi exhibit differential adhesion to monkey and human erythrocytes

Table 2 Binding profile of erythrocytes from various primate and non-primate species to PkNBPXb-II expressing COS7 cells

Common Name	Scientific Name	Regional Classification	Geographical Range	RBC* Rosettes	rPkNBPXb-II Binding
Rhesus Macaque	Macaca mulatta	Old World	India, China, Thailand	21.2+/−17.6	Yes
Long-tailed Macaque	Macaca fascicularis	Old World	Southeast Asia	87.5+/−31.6	Yes
Pigtail Macaque	Macaca nemestrina	Old World	Southeast Asia	19.0+/−7.8	Yes
Sooty Mangabey	Cercocebus atys	Old World	West Africa	85.0+/−42.7	Yes
Owl Monkey	Aotus nancymaae	New World	South America	0.0	No
Squirrel Monkey	Saimiri boliviensis	New World	South America	0.0	No
Capuchin	Cebus apella	New World	South America	0.0	No
Marmoset	Callithrix jaccus	New World	South America	0.0	No
Tamarin	Saguinus midas	New World	South America	2.4+/−2.6	weak
Human	Homo sapiens	Great Apes	Worldwide	0.0	No
Chimpanzee	Pan troglodytes	Great Apes	West and Central Africa	0.0	No
Gibbon	Hylobates lar	Lesser Apes	Southeast Asia	49.6+/−31.4	Yes
Rabbit	Oryctolagus cuniculus	Rabbit		4.1+/−6.6	weak
Mouse	Mus musculus	Mouse		0.0	No

*Mean number and standard deviation of COS7 cells with surface bound rosettes of erythrocytes per 50 fields of 40x objective.

ISSN: 1475-2875