Phylogenetic comparison of var group A from 3D7 genome and 3 dominant var group A amplified from clinical isolates. A neighbor-joining tree was generated based upon the predicted protein start site in the N-terminal segment (NTS) domain to the first DBL-1α H block. The bootstrap consensus tree inferred from 1000 replicates , using pairwise deletion of amino acid sequences with p-distance. Phylogenetic analyses were conducted in MEGA4 . Sequences transcribed by isolates from children with severe malaria (ISM, blue), asymptomatic (AS, green).