Table 2 Outcome at day 28 and 42 for all patients
Treatment outcome | Day 28 | Day 42 |
|---|---|---|
Lost to follow-up (%) | 31/348 (8.9) | 32/348 (9.2) |
Inability to tolerate oral treatment1 (%) | 2/348 (0.6) | 2/348 (0.6) |
Early treatment failure (%) | 0 | 0 |
Late treatment failure (%) | 3/348 (0.9) | 28/348 (8.0) |
Late clinical failure (%) | 3/348 (0.9) | 16/348 (4.6) |
Late parasitological failure | 0 | 12/348 (3.4) |
ACPR | 312/348 (89.7) | 286/348 (82.2) |
Infection with different species (%) | 0 | 0 |
New infection P. falciparum (%) | 1/348 (0.3) | 12/348 (3.4) |
Recrudescences (%) | 2/348 (0.6) | 16/348 (4.6) |
Cure rate per protocol, PCR-uncorrected (%, 95% CI) | 312/315 (99.1, 98.0-100.0) | 286/314 (91.1, 87.9-94.3) |
Cure rate per protocol, PCR-corrected (%, 95% CI) | 312/314 (99.4, 98.5-100.0) | 286/302 (94.7, 92.2-97.2) |
Cure rate intention-to-treat, PCR-uncorrected (%, 95% CI) | 312/348 (89.7, 86.4-92.9) | 286/348 (82.2, 78.1-86.2) |
Cure rate intention-to-treat, PCR-corrected (%, 95% CI) | 312/347 (89.9, 86.7-93.1) | 286/336 (85.1, 81.3-88.9) |