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Table 1 Association between parasitaemia and different point mutations of pfcrt and pfmdr1 genes

From: The detection of pfcrt and pfmdr1 point mutations as molecular markers of chloroquine drug resistance, Pahang, Malaysia

Locus Alleles Parasitaemia χ 2 significance
Low (< 1,000/μl) Moderate to high (≥1,000/μl)
Pfcrt 76 Mutant 8 31 <0.001
Wild 23 13  
Pfcrt 271 Mutant 0 4 0.138*
Wild 31 40  
Pfcrt 326 Mutant 0 9 0.009*
Wild 31 35  
Pfcrt 356 Mutant 1 17 <0.001*
Wild 30 27  
Pfcrt 371 Mutant 22 36 0.409
Wild 9 8  
Pfmdr1 -86 Mutant 0 4 0.138*
Wild 31 40  
Pfmdr1 -1246 Mutant 0 3 0.263*
  Wild 31 41  
  1. * Fisher’s Exact test.