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Table 1 Association between parasitaemia and different point mutations of pfcrt and pfmdr1 genes

From: The detection of pfcrt and pfmdr1 point mutations as molecular markers of chloroquine drug resistance, Pahang, Malaysia

Locus

Alleles

Parasitaemia

χ 2 significance

Low (< 1,000/μl)

Moderate to high (≥1,000/μl)

Pfcrt 76

Mutant

8

31

<0.001

Wild

23

13

 

Pfcrt 271

Mutant

0

4

0.138*

Wild

31

40

 

Pfcrt 326

Mutant

0

9

0.009*

Wild

31

35

 

Pfcrt 356

Mutant

1

17

<0.001*

Wild

30

27

 

Pfcrt 371

Mutant

22

36

0.409

Wild

9

8

 

Pfmdr1 -86

Mutant

0

4

0.138*

Wild

31

40

 

Pfmdr1 -1246

Mutant

0

3

0.263*

 

Wild

31

41

 
  1. * Fisher’s Exact test.