Figure 1
From: Anti-plasmodial action of de novo-designed, cationic, lysine-branched, amphipathic, helical peptides
Multivalent cationic, amphipathic helical peptides are potent inhibitors of the growth of malaria parasite in culture. Dose-dependent effects of ΔFm (monomer), [(ΔFm)2 and ΔFd] (dimers) and ΔFq (quadrumer) on the growth of ring-stage synchronized Plasmodium falciparum (3D7) culture of malaria parasite. The anti-plasmodial potency increases in going from monomer ΔFm, to dimers [ΔFd, and (ΔFm)2] and the quadrumer ΔFq. The marginal difference in the comparative growth inhibition profiles of the two dimers at 48 hr vs 96 hr suggests that there is predominantly early death. Each data point represents the mean+/− SD of three replicates.