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Table 1 In-vitro blood stage antiplasmodial activities, resistance and selectivity indices of peptides against different strains of P. falciparum

From: Anti-plasmodial action of de novo-designed, cationic, lysine-branched, amphipathic, helical peptides

Peptides Peptide Sequence and design IC50P. falciparum(μM) Resistance index HC50URBC μM
3D7 Dd2 INDO IC50Dd2/ IC503D7
Fm Ac-GFRKFHKFWA-NH 2 >100 >100   - >100
ΔFm Ac-GΔFRKΔFHKΔFWA-NH 2 >100 >100 - - >100
ΔFd 1.39 ± 0.1 1.6 ± 0.09 1.5 ± 0.075 1.15 >50 ( >35)*
D-Lys-ΔFd** 1.8 ± 0.07 - - - >50 (> 27)
Fd 1.5 ± 0.08 - - - >50 (>33)
(ΔFm) 2 Ac-GΔFRKΔFHKΔFWAAGΔFRKΔFHKΔFWA-NH 2 2.4 ± 0.15 2.5 ± 0.13 - 1.04 >50 (>20)
ΔFq 0.25 ±0.02 - - - 2.5 ±0.13 (10)
Prochitinase EEPHKAASAEGKK > 40 - - - > 40
E30 NPPDHSAPLGATRPSAPPLPHVVDLPQLGP > 40 - - - > 40
Insulin > 40 - - - > 40
Artemisinin 0.015 0.016 0.015 1  
Chloroquine 0.04 0.16 0.5 4  
  1. * Hemolytic Selectivity index (HC50URBC/ IC50Pf 3D7) is shown in parenthesis, **: KD refers to Lysine of D configuration. Values of standard deviation given as ± are based on three independent observations.