Skip to main content

Table 2 Putative metabolites observed after one-hour incubation with recombinant human MAO-A, 2D6, 3A4, and 2 C19 with retention times (rt), observed m/z and transitions

From: CYP450 phenotyping and accurate mass identification of metabolites of the 8-aminoquinoline, anti-malarial drug primaquine

Putative metabolite

rt (min)

m/z(transition)

MAO-A

2D6

3A4

2 C19

Parent

6.98

260.3 → 175.1

60

80

99

98

PQ-alcohol

8.2

261.3 → 175.1

38

   

CPQ

8.4

275.3 → 175.1

<1

   

Ox1 (quinoline core)

5.0

276.3 → 191.1

 

5

  

Ox2 (quinoline core)

6.1

276.3 → 191.1

 

6

  
  1. Tabulated data represents % of the total chromatographic peak area for each component. These values provide a qualitative relative measure of the metabolites produced in these incubations and should not be construed in any way as quantitative measurements.