From: Hyponatraemia in imported malaria: the pathophysiological role of vasopressin
Parameter | Hyponatraemic patients (n = 13) | Normonatraemic patients (n = 10) | |||
---|---|---|---|---|---|
 | Inappropriate AVP secretion@ (n = 7) | Appropriate AVP secretion (n = 6) | P-value# |  | P-value* |
Vital signs on admission | Â | Â | Â | Â | Â |
Body temperature, °C | 38.9 (37.6-41.1) | 37.4 (35.7-38.6) | P = 0.0153 | 38.3 (36.0-40.1) | n.s. |
Pulse rate, beats per minute | 96 (72-121) | 105 (91-120) | n.s. | 93 (72-125) | n.s. |
Laboratory data on admission | Â | Â | Â | Â | Â |
C-reactive protein, mg/L | 158 (60-176) | 236 (71-352) | n.s. | 95 (18-407) | n.s. |
Haematocrit, L/L | 0.39 (0.15-0.44) | 0.40 (0.19-0.50) | n.s. | 0.46 (0.36-0.51) | n.s. |
Serum Urea:creatinine ratio | 0.06 (0.04-0.11) | 0.07 (0.05-0.14) | n.s. | 0.06 (0.03-0.09) | n.s. |
Serum copeptin, pmol/L | 11.4 (7.2 -21.4 ) | 23.5 (6.8 -91.5 ) | n.a. | 12.2 (3.8-49.7) | n.a. |
Serum copeptin > P97.5, n (%) | 4 (57) | 5 (83) | n.s. | 6 (60) | n.s |
Serum sodium, mmol/L | 132 (131-134) | 128 (124-132) | P = 0.012 | 138 (135-141) | n.a. |
Urine osmol, mosmol/kg | 780 (540-924) | 480 (298-532) | P = 0.0022 | 484 (234-906) | P = 0.047 |
Urine sodium, mmol/L | 49 (38-154) | 9 (9-47) | n.a. | 32 (9-164) | n.a. |