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Table 5 Function and details of identification of the significant SNPs associated with high levels of each anti-malarial antibody levels and total IgE levels

From: Genetic polymorphisms associated with anti-malarial antibody levels in a low and unstable malaria transmission area in southern Sri Lanka

Antibody Significant SNPs Chromosome (Position) Gene Allele associated p Function
AMA1_Pf rs25882 5 (131411460) CSF2 T 0.039 NS
rs1881457 5 (131992409) IL13 T 0.047 S
rs334 11 (5248232) HBB A 0.008 NS
rs1799969 19 (10394792) ICAM1 G 0.043 NS
MSP1_Pf rs2706348 5 (131933709) RAD50 G 0.039  
rs2227478 12 (68648622) IL22 A 0.043 S
MSP2 NONE      
NANP rs7537937 1 (89582690) GBP7 C 0.003 NS
rs1800872 1 (206946407) IL10 T 0.033 S
rs1800871 1 (206946634) IL10 A 0.031 S
rs25887 5 (131416061) CSF2 C 0.013 NS
rs156029 5 (131532634) P4HA2 A 0.0007  
rs272867 5 (131681057) SLC22A4 G 0.039  
rs1881457 5 (131992409) IL13 T 0.019 S
rs334 11 (5248232) HBB A 0.001 NS
AMA1_Pv rs4986790 9 (120475302) TLR4 A 0.039 NS
rs1801033 5 (41199959) C6 A 0.049 NS
MSP1_Pv rs1801274 1 (161479745) FCGR2a T 0.018 NS
rs156029 5 (131532634) P4HA2 A 0.016  
rs848 5 (131996500) IL13 G 0.030 S
rs2242665 6 (31821494) CTL4 A 0.015 NS
rs7935564 11 (5718517) TRIM5 A 0.025 NS
rs10775349 16 (4079823) ADCY9 G 0.042 S
Total IgE rs7537937 1 (89582690) GBP7 C 0.024 NS
rs1518110 1 (206944861) IL10 C 0.002 S
rs1800872 1 (206946407) IL10 T 0.001 S
rs1800871 1 (206946634) IL10 A 0.001 S
rs2243250 5 (132009154) IL4 C 0.023 S
rs2243270 5 (132014109) IL4 T 0.039 S
  rs3177244 22 (24179132) DERL3 G 0.043 NS
  1. NS: non-synonymous, S: synonymous.