Figure 8

Examples of detected infections for three symptomatic children over the study period demonstrating P. falciparum density and haplotypes detected. The red arrow denotes the week each child developed symptomatic clinical malaria and was retreated with Coartem®. The X axis denotes the week of the study and the Y axis denotes P. falciparum density by MFI. In Panel A, P. falciparum infection was detected several weeks prior to symptoms. With low parasitaemia, only a single haplotype (EKNG) was detected. It may be that amplifying the Q allele was below the threshold of detection with low parasitaemia. In Panel B, Coartem® administration was followed by a rapid decline of detectable parasitaemia, but increases in parasitaemia were seen in weeks 7–9. Panel C shows infections in weeks 3–6 with ENKG/QKNG haplotypes. In week 7, a new haplotype QTSR was detected prior to the development of clinical malaria.