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Table 3 MIR and associated IC50 fold increase reported in the literature

From: A framework for assessing the risk of resistance for anti-malarials in development

Compound

Strain

Pressure

MIR

IC50fold increase

Mechanisma

Ref.a

Atovaquone

W2

10×IC50

1×105

30x

n/a

[47]

Atovaquone

K1

6×/16×IC50

6×108

900x

single point mutations in pfcytb

[4]

Piperaquine

Dd2

2×IC50

8.5×108

100x

63-kb fragment amplification

[49]

Chloroquine

106/1

3×IC50

6×108

100x

single point mutations in pfcrt

[52]

GSK2645947

3D7

10×IC50

<108

100x

n/a

[51]

  1. an/a:non available.