From: A framework for assessing the risk of resistance for anti-malarials in development
Compound | Strain | Pressure | MIR | IC50fold increase | Mechanisma | Ref.a |
---|---|---|---|---|---|---|
Atovaquone | W2 | 10×IC50 | 1×105 | 30x | n/a | [47] |
Atovaquone | K1 | 6×/16×IC50 | 6×108 | 900x | single point mutations in pfcytb | [4] |
Piperaquine | Dd2 | 2×IC50 | 8.5×108 | 100x | 63-kb fragment amplification | [49] |
Chloroquine | 106/1 | 3×IC50 | 6×108 | 100x | single point mutations in pfcrt | [52] |
GSK2645947 | 3D7 | 10×IC50 | <108 | 100x | n/a | [51] |