Figure 2

Visual Predictive Check of plasma artemether and dihydroartemisinin concentrations. Upper panel: open circles represent the observed data, the solid lines the 5^th, 50^th and 95^th percentiles of the observed data and the shaded area the 95% confidence intervals of the 5^th, 50^th and 95^th percentiles of the simulated plasma concentrations (nmol/L). The limit of quantification is represented by the black dashed line. Lower panel: the shaded area represents the simulated 95% confidence intervals for the fraction of BQL data. The black solid line represents the observed fraction of BQL data.