Table 1 Demographic information of the study population

Number of patients

21

Total artemether dose (mg/kg)

8.46 ± 1.22

8.73 [5.46-9.80]

Total number of samples

316

Sample size (samples/patient)

15.0 ± 0.805

15 [12-16]

covariates

Body weight (kg)

58.1 ± 10.1

55 [49-88]

Age (years)

21.4 ± 4.28

21 [16-35]

Gestational age (weeks)

25.8 ± 7.77

27 [13-36]

Haemoglobin (g/dL)

11.1 ± 1.72

11.3 [7.6-14.6]

Red blood cell count (10⁶ cells/cmm)

3.74 ± 0.629

3.71 (2.37-4.79)

Haematocrit (%)

33.7 ± 5.14

34.0 (23.2-44.5)

Neutrophils (counts/μL)

2.73 ± 0.802

2.75 (1.14-4.13)

Eosinophils (counts/μL)

0.130 ± 0.148

0.0700 [0.0200-0.570]

Basophils (counts/μL)

0.0280 ± 0.0140

0.0200 [0.0100-0.0600]

Lymphocytes (counts/μL)

2.08 ± 0.667

1.98 [1.12-3.51]

Monocytes (counts/μL)

0.590 ± 0.214

0.550 [0.260-1.00]

Platelets (10³/cmm)

166 ± 62.0

167 [64-285]

Alanine aminotransferase (IU/L)

16.1 ± 6.77

14.0 [5.00-35.0]

Creatinine (mg/dl)

0.481 ± 0.103

0.470 [0.330-0.660]

Bilirubin (mg/dl)

1.24 ± 1.10

0.910 [0.560-5.53]

Diastolic blood pressure (mmHg)

60.1 ± 6.20

60.0 [46.0-75.0]

Temperature (°C)

36.8 ± 0.747

36.7 [36.0-38.5]

P. falciparum parasitaemia (parasites/μL)

10900 ± 32000

1570 [88.0-148000]