Table 4 A comparison of the artemether pharmacokinetic properties to literature values

Parameter

AUC (hr × ng/ mL/mg dose)

C_MAX (ng/mL/ mg dose)

T_MAX (hr)

T_1/2 (hr)

CL (L/hr/kg)

Pregnant women with uncomplicated malaria

Final model (N = 21)

Median (range)^a

1.34 (0.203-3.75)

0.411 (0.0930-1.04)

1.16 (0.653-3.81)

1.77 (0.773-2.49)

15.1 (18.6)^b

NCA (N = 21)

Median (range)

1.21 (0.09-4.26)

0.443 (0.0710-1.79)

1.27 (0.500-4.00)

1.96 (0.590-4.01)

13.2 (3.21-130)

NCA in Thai pregnant patients (N = 13)[9]

Median (90% ranges)

0.820 (0.131-3.50)

0.438 (0.175-1.30)

1.00 (0.500-2.00)

1.50 (1.20-7.20)

25.9 (6.00–162)

Non-pregnant patients with uncomplicated malaria

NCA in Thai patients (N = 25)[52]

Mean ± S.D.

2.64 ± 1.36

0.828 ± 0.679

2.0 (1.00-8.00)

2.20 ± 1.00

-

NCA in Thai patients (N = 13)[54]^c

Mean (range)

6.03 (3.21-10.23)

1.12 (0.73-1.50)

2.0 (2.0-2.0)

2.6 (1.8-4.7)

3.27

Healthy subjects

NCA in Pakistani subjects (N = 12)[42]^d

Median (range)

4.53 (1.60-8.30)

2.16 (0.678-4.54)

1.50 (0.500-3.00)

1.88 (1.24-4.00)

3.11 (1.57-11.9)

NCA in Caucasian subjects (N = 14)[53]

Mean ± S.D.

0.791 ± 0.906

0.343 ± 0.386

1.5 [1–4]

1.6

-

NCA in Caucasian subjects (N = 8)[50]^e

Mean ± S.D.

0.350 ± 0.300

0.190 ± 0.130

1.60 ± 0.800

0.500 ± 0.100

-