Skip to main content

Table 1 Distribution of amino acids repeat sequences of Pfhrp2 and Pfhrp3 in different regions of India

From: Genetic variation in histidine rich proteins among Indian Plasmodium falciparum population: possible cause of variable sensitivity of malaria rapid diagnostic tests

Type of Repeat Repeat Sequences in Pfhrp2/Pfhrp3 Antigens observed No. of individual repeats in different regions of India Total Repeats
Pfhrp2 Pfhrp3 Chhattisgarh West Bengal M.P. Gujarat Orissa Karnataka
1 AHHAHHVAD + - 1-2 1-3 1-4 1-2 1-3 1-2 1-4
2 AHHAHHAAD + - 2-14 2-15 2-9 3-11 2-11 2-11 2-14
3 AHHAHHAAY + - 0-1 0-1 0-1 0-1 1-2 0-1 0-2
4 AHH + - 1-3 0-2 0 0-2 0-2 0-2 0-3
  AHH - + 0 0-1 0 0-2 0-2 0 0-2
5 AHHAHHASD + - 0 0-2 0-1 0-1 0-1 0-2 0-2
6 AHHATD + - 0-4 0-2 0-1 0-1 0-5 0-2 0-2
7 AHHAAD + - 0-1 0-2 1-2 1-6 1-5 0-3 0-4
  AHHAAD - + 0-1 0-1 1-2 0-1 1-2 0-1 0-2
8 AHHAAY + - 0 1-2 0-1 0-1 0-1 0-1 0-2
9 AHHAPH + - 0-1 0 0 0 0 0 0-1
10 AHHAPD + - 0-1 0 0 0 0 0 0-1
11 AHVDD + - 0-1 0-1 0-1 0-1 0-1 0-1 0-1
12 AHHAA + - 0-2 0-1 0-2 0 0-3 0-2 0-1
13 AHHEAA + - 0-1 0-1 0-1 0 0 0 0-1
14 AHHAAN - + 2-15 2-12 2-9 3-11 2-14 3-12 2-15
15 AHHDGAHHDD - + 1-2 1-2 1-2 1-2 1-2 1-2 1-2
16 AHHDGAHHDG - + 0-2 1-2 1-2 0-2 1-2 1-2 0-2
17 AHHDG - + 0-2 0 0 0 0 0 0-2
18 AHHN - + 0-2 0 0 0 0 0 0-2
  1. Note: Bold letters - Pfhrp2 sequences, Italic – Pfhrp3 sequences.