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Figure 2 | Malaria Journal

Figure 2

From: Assessing the utility of an anti-malarial pharmacokinetic-pharmacodynamic model for aiding drug clinical development

Figure 2

Distribution of proportion cured within the EC50 and k max deciles derived from the 5000 parameter sets for the anti-malarial combination therapy, artesunate (ARS) and mefloquine (MQ). Top panels are for artesunate (EC50 – left hand side, kmax right hand side) and bottom panels are for mefloquine (EC50 – left hand side, kmax right hand side). Each individual box (with whiskers) represents the distribution of the proportion cured simulated for 5000 parameter values of EC50 (or kmax) within the range of cut-off values of that decile grouping, all other parameters were varied.

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