|
IC50 measured concentration(nM)†
|
1.39
|
-
|
13.42
|
9.34
|
17.67
|
|
Molecular weight (g/mol)
|
384.4
|
-
|
528.9
|
378.3
|
535.5
|
|
IC50 concentration(ng/mL)
|
0.53
|
2.64
|
7.1
|
3.53
|
9.46
|
|
Binding to media of in vitro experiment (0.5% Albumax) (% bound)
|
82.8
|
82.8
|
99.6
|
85
|
98.1
|
|
Human plasma protein binding (% bound)
|
93
|
91.7
|
98.7
|
95.6
|
98.6
|
|
Human whole blood to plasma ratio
|
1.1
|
0.8
|
0.8
|
1.7
|
0.9
|
|
Scalar (adjusted)
|
2.7
|
1.66
|
0.25
|
5.8
|
1.22
|
|
IC50 (adjusted) concentration (ng/mL)†
|
1.44
|
4.38
|
1.75
|
20.48
|
11.56
|
|
γ (Slope of concentration-effect curve)
|
3.72
|
4.61
|
2.24
|
2.63
|
3.48
|
|
SD of γ on log-scale
|
0.65
|
0.31
|
0.58
|
0.54
|
0.66
|
