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Table 5 Parameter values derived from in vitro experiments
| Parameter | ARS/DHA | ART | LF | MQ | PQ |
|---|---|---|---|---|---|
| IC50 measured concentration(nM)† | 1.39 | - | 13.42 | 9.34 | 17.67 |
| Molecular weight (g/mol) | 384.4 | - | 528.9 | 378.3 | 535.5 |
| IC50 concentration(ng/mL) | 0.53 | 2.64 | 7.1 | 3.53 | 9.46 |
| Binding to media of in vitro experiment (0.5% Albumax) (% bound) | 82.8 | 82.8 | 99.6 | 85 | 98.1 |
| Human plasma protein binding (% bound) | 93 | 91.7 | 98.7 | 95.6 | 98.6 |
| Human whole blood to plasma ratio | 1.1 | 0.8 | 0.8 | 1.7 | 0.9 |
| Scalar (adjusted) | 2.7 | 1.66 | 0.25 | 5.8 | 1.22 |
| IC50 (adjusted) concentration (ng/mL)† | 1.44 | 4.38 | 1.75 | 20.48 | 11.56 |
| γ (Slope of concentration-effect curve) | 3.72 | 4.61 | 2.24 | 2.63 | 3.48 |
| SD of γ on log-scale | 0.65 | 0.31 | 0.58 | 0.54 | 0.66 |
