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Table 3 Family-based association analyses for anti- Plasmodium falciparum IgG subclass levels

From: Malaria resistance genes are associated with the levels of IgG subclasses directed against Plasmodium falciparum blood-stage antigens in Burkina Faso

 

IgG1

IgG2

IgG3

IgG4

Locus

Pa

Pa

Pa

Pa

IL12Bpro

P > 0.05

P > 0.05

P > 0.05

P > 0.05

IL12B3’UTR

P > 0.05

P > 0.05

P > 0.05

P > 0.05

IL4-590

P > 0.05

P > 0.05

Cb (0.0472d)

P > 0.05

FCGR2A H/R131

P > 0.05

T b (0.0003 e,f )

C b (0.0010 d,f )

P > 0.05

HbC

P > 0.05

Cb (0.0139d)

P > 0.05

P > 0.05

HbS

P > 0.05

P > 0.05

P > 0.05

P > 0.05

LTA + 80

Ab (0.0305c)

Ab (0.0505c)

Ab (0.0214c)

Ab (0.0139c)

TNF- 1031

P > 0.05

P > 0.05

P > 0.05

P > 0.05

TNF-863

Ab (0.0379c)

P > 0.05

A b (0.0082 c,f )

P > 0.05

TNF-857

P > 0.05

P > 0.05

Tb (0.0413c)

Tb (0.0249c)

TNF-308

P > 0.05

P > 0.05

P > 0.05

P > 0.05

TNF-238

P > 0.05

P > 0.05

P > 0.05

P > 0.05

TNF 1304

Ab (0.0495c)

P > 0.05

A b (0.0099 c,f )

A b (0.0108 c,f )

NCR3-412

P > 0.05

P > 0.05

P > 0.05

P > 0.05

NCR3*3790

P > 0.05

P > 0.05

Cb (0.0276c)

Cb (0.0196c)

  1. Abbreviations: HbC, Haemoglobin C; IgG, Immunoglobulin G; IL4, Interleukin 4; LTA, Lymphotoxin-α; NCR3, Natural cytotoxicity receptor 3; P. falciparum, Plasmodium falciparum; TNF, Tumour necrosis factor.
  2. aChi-square test P-value.
  3. bAllele positively associated.
  4. cAdditive model.
  5. dDominant model.
  6. eRecessive model.
  7. fSignificant P value after applying a false discovery rate of 10%.
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Malaria Journal

ISSN: 1475-2875

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