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Table 1 Representative VOCs detected in control and P. falciparum infected cultures using SPME (triple fibre) coupled with GC-MS (Figure 2 )

From: Investigation of volatile organic biomarkers derived from Plasmodium falciparum in vitro

   Relative abundance (%)
Retention time (mins) Compound Control cultures P. falciparum- infected cultures
1.81 carbon dioxide 3539462 (1.39) 1554307 (0.62)
2.64 octane 646353 (0.25) 783376 (0.31)
3.40 2,4-dimethyl-1-heptene 623570 (0.24) 615473 (0.24)
4.14 octamethyl tetrasiloxane* 724464 (0.28) 560807 (0.22)
4.33 2,2,4,6,6-pentamethyl heptane 7031090 (2.76) 8250249 (3.28)
4.45 4-methyl nonane 609038 (0.24) 638770 (0.25)
5.22 2,6-dimethyl nonane 1740986 (0.68) 1668518 (0.66 )
5.36 decane 6616172 (2.59) 7986280 (3.18)
5.50 branched alkane (C11H24) 1452353 (0.57) 1453227 (0.58)
6.07 2,6-dimethyl decane 947057 (0.37) 1061297 (0.42)
6.17 3,7-dimethyl decane 716160 (0.28) 716355 (0.28)
6.59 toluene 1000764 (0.39) 962309 (0.38)
6.70 branched alkene (C11H22) 1145337 (0.45) 1218163 (0.48)
6.92 unidentified siloxane* 2167416 (0.85) 3703832 (1.47)
7.44 dodecane 983881 (0.39) 1189196 (0.47)
7.82 branched alkane (C12H26) 698815 (0.27) 1644428 (0.65)
8.03 branched alkene (C12H24) 2883283 (1.13) 2925879 (1.16)
8.13 branched alkene (C12H24) 2891039 (1.13) 2873277 (1.14)
9.59 alpha-pinene 516866 (0.20) 762074 (0.30)
10.17 3-heptanone 514761 (0.20) 518528 (0.21)
10.77 isopropyl benzene 404573 (0.16) 498258 (0.20)
11.36 unidentified alkane 910196 (0.36) 725047 (0.29)
11.57 D-limonene 451954 (0.18) 398652 (0.16)
13.22 2-pentyl furan 979481 (0.38) 1209153 (0.48)
15.28 cyclohexanone 3714649 (1.46) 4124560 (1.64)
19.66 cyclohexanol 558229 (0.22) 682196 (0.27)
20.49 1,3-di-tert-butylbenzene 10159046 (3.98) 7908796 (3.15)
21.28 1-octen-3-ol 796995 (0.31) 1909838 (0.76)
22.56 2-ethyl-1-hexanol* 198435706 (77.77) 191847968 (76.31)
23.23 unidentified alkane 1285623 (0.50) 1027694 (0.41)
  1. *known contaminants.
  2. Compounds were tentatively identified (> 95% similarity) by comparing the experimental mass spectra obtained with known compounds present in a commercial library of mass spectra (NIST05).