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Table 1 Reactivity of MSP1 specific T cells from BALB/c mice demonstrates strong strain-specificity

From: Impact of pre-existing MSP142-allele specific immunity on potency of an erythrocytic Plasmodium falciparum vaccine

Regimen IFN-γ responsesa Il-4 responsesa
  MSP142 MSP142
  CAMPb FVO 3D7 CAMP FVO 3D7
FVO → FVO + +++ + +/− + +/−
FVO → 3D7 + ++ ++ +/− +/− +/−
FVO → CAMP + ++ +/− + +/− +/−
3D7 → 3D7 + +/− ++ + +/− +++
3D7 → FVO +/− ++ + +/− +/− +
3D7 → CAMP ++ +/− ++ + ++ ++
3D7/FVO mix + ++ ++ +/− +/− +
CAMP → CAMP +++ + + ++ +/− +/−
CAMP → 3D7 ++ +/− + + +/−  
CAMP → FVO + + +/− + +/− +/−
  1. a Strength of response: + ≥ 15 SFC, ++ ≥30, +++ ≥ 45 SFC. Responses of mice immunized with saline/Montanide ISA-720 did not exceed 2 ± 1 SFC/106 splenocytes when stimulated with any of the antigens used. Responses of splenocytes stimulated with GST as the control antigen did not exceed 2 ± 2 SFC/106 splenocytes.
  2. b MSP142 allele used for ex vivo stimulation. Bold characters highlight the magnitude of the homologous response.