Table 2 Treatment of uncomplicated falciparum malaria in adults[79]
| Â | Adult Patients | Â | Â |
|---|---|---|---|
| Â | Drug | Dosage | Comment |
First line | Artemether/Lumefantrine (Riamet™) | Twice daily for three days >35 kg: 4 tablets each 20 mg/120 mg for 6 doses (0–8–24–36–48–60 hours) | Take with fatty food, reduced efficacy in Cambodia and border regions of Thailand |
|  | Dihydroartemisinin/Piperaquine (Eurartesim™)° | Once daily for three days 36 <75 kg: 3 tablets each 320 mg/40 mg, 75-100 kg: 4 tablets each 320 mg/40 mg, daily for three days | Administration without food, at least 3 hours from any meal |
| Â | Atovaquone/Proguanil (Malaroneâ„¢) | Once daily for 3 days >40 kg: 4 tablets each 250/100 mg | Administration with fatty food |
Second line | Quinine*/Doxycycline | Thrice daily 10 mg/kg quinine plus daily 200 mg doxycycline for 7 days | Loose drug combination, off-label use |
| Â | Quinine*/Clindamycin | Thrice daily 10 mg/kg quinine plus twice daily 10 mg/kg clindamycin for 7 days | Loose drug combination, off-label use |
|  | Mefloquine (Lariam™) | Split total dose in 2–3 doses 6–8 hours apart 45-60 kg: 5 tablets (3 + 2 tablets) >60 kg: 6 tablets (3 + 2 + 1 tablets) | Administration after food intake monotherapy, which is not suitable for regions with multidrug resistant falciparum malaria (SE-Asia) |