Management of imported malaria in Europe

Malaria Journal

Table 7 Drug interactions between antimalarial and antiretroviral medication

Drugs	Mefloquine	Atovaquone	Proguanil	Chloroquine	Artemisinins	Quinine
Protease inhibitors
Saquinavir	-	+	-	-	?	+
Ritonavir	-	+	+	+	+	+
Indinavir	-	+	-	-	?	+
Nelfinavir	-	+	-	-	?	+
Amprenavir	-	+	-	-	?	+
Lopinavir	-	+	-	-	+	+
Atazanavir	-	+	-	-	?	+
NNRTIs ⁽¹⁾
Nevirapine, efavirenz and others	-	-	-	-	?	+
NRTIs ⁽²⁾
Zidovudine and others	-	-	-	-	-	-

(1) Non-Nucleoside Reverse Transcriptase Inhibitors.
(2) Nucleoside Reverse Transcriptase Inhibitors.
- No clinically significant interaction, or interaction unlikely based on knowledge of drug metabolism.
+ Potential interaction that may require dose monitoring, alteration of drug dosage or timing of administration.

ISSN: 1475-2875