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Table 3 Association between malaria retinopathy and infections caused by a single/less complex genotypes (vs three or more).

From: Human cerebral malaria and Plasmodium falciparum genotypes in Malawi

 

Single/Less Complex

Genotype

Multiple

Genotypes

 
 

(< 3 Het. Calls)

(=3 Het. Calls)

 
 

(N = 52)

(N = 51)

 

Retinopathy

42 (81%)

27 (53%)

 

No retinopathy

10

24

 
 

Logistic Regression

  
 

(N = 67 with and 32 without retinopathy)

 

Unadjusted Model†

OR

(95% CI)

P*

Single/Less Complex (vs. 3 Hets)

3.7

(1.51-9.10)

0.003

Adjusted Model†

Single/Less Complex (vs. ≥ 3 Hets)

4.82

(1.59-14.30)

0.003

Hematocrit

0.84

(0.79, 0.96)

< 0.0001

Parasites/μl (natural logarithm)

1.36

(0.996, 1.85)

0.046

Time (weeks from January until date of sample collection)

0.87

(0.77-0.92)

0.001

  1. Frequencies and odds ratios (OR) obtained in logistic regression models. Four patients were removed from regression modeling due to missing data
  2. Het. = Heterozygous; OR = Odd Ratio; CI = Confidence Interval
  3. *P-values were estimated using likelihood-ratio tests.
  4. † c-statistic (corresponding to the area under the ROC curve of the fitted model) of the unadjusted model was 0.66 and of the adjusted model was 0.82.