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Table 3 Frequency distribution of putative SNPs and haplotypes of pfatpase6 gene in 226 P. falciparum isolates unexposed (<2007) and exposed (>2007) to ACT

From: Molecular assessment of atpase6 mutations associated with artemisinin resistance among unexposed and exposed Plasmodium falciparum clinical isolates to artemisinin-based combination therapy

Gene pfatpase6 Year Total
Haplotype L263E E431K A623E S769N <2007* 2007** 2008-2010*** n=226 (%)
n=35 (%) n=49 (%) n=142 (%)
LEAS L E A S 27 (77) 44 (89.8) 110 (77.5) 181 (80)
LK AS L K A S 8 (23) 4 (8.2) 25 (17.6) 37 (16.4)
LEA(SN) L E A SN - 1 (2) 2 (1.4) 3 (1.3)
L(EK)AS L EK A S - - 3 (2.1) 3 (1.3)
LK A(SN) L K A SN - - 1 (0.7) 1 (0.5)
L(EK)A(SN) L EK A SN - - 1 (0.7) 1 (0.5)
  1. * Unexposed P. falciparum isolates to ACT.
  2. ** Exposed to ACT with high pressure.
  3. *** Exposed to ACT introduction of ACT as first-line anti-malarial therapy for 4 years.