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Table 4 Sequence analysis of SNPs in full-length pfatpase6 among 40 P. falciparum clinical isolates unexposed (n = 20) and exposed (n = 20) to ACT

From: Molecular assessment of atpase6 mutations associated with artemisinin resistance among unexposed and exposed Plasmodium falciparum clinical isolates to artemisinin-based combination therapy

A: Nonsynonymous

     

Position

≤2007

>2007

nt

aa

 

Codon

n=20

n=20

266

89

T

AcA

0.25

0

  

I

AtA

0.75

1

689

230

I

AtC

0.95

1

  

T

AcC

0.05

0

1063

355

I

aTA

1

0.7

  

L

tTA

0

0.3

1291

431

E

gAA

0.45

0.40

  

K

aAA

0.55

0.60

1707

569

K

AAa

0.25

0

  

N

AAt

0.75

1

1888

630

T

aCT

0

0

  

H

gCT

0.95

1

  

S

tCT

0.05

0

2049

683

K

AAa

0

0.05

  

N

AAt

1

0.95

2306

769

S

AgT

1

0.87

  

N

AaT

0

0.13

2610

870

F

TTt

1

0.95

  

L

TTa

0

0.05

B: Syonymous

     

981

327

A

GCa

0.05

0

  

A

GCt

0.95

1

1449

483

N

AAc

0.2

0

  

N

AAt

0.8

1

2694

898

I

Ata

0.8

0.95

  

I

ATt

0.2

0.05

2703

901

V

GTa

0.95

1

  

V

GTt

0.05

0

3090

1030

K

AAa

0.05

0.05

  

K

AAg

0.95

0.95

3093

1031

C

TGc

0.95

1

  

C

TGt

0.05

0

3309

1103

Y

Tat

0.95

1

  

Y

TAc

0.05

0

  1. nt: nucleotide.
  2. aa: amino acid.
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Malaria Journal

ISSN: 1475-2875

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