Figure 2From: Improving N-terminal protein annotation of Plasmodium species based on signal peptide prediction of orthologous proteinsDescription of orthologous groups classified based on signal peptide prediction of their proteins. (A) Distribution of 4319 groups from different Plasmodium species: Pv (P. vivax); Pk (P. knowlesi); Pf (P. falciparum); Pb (P. berghei); Py (P. yoelii). Horizontal lines represent each orthologous group. White spaces represent the lack of a protein in the species for that orthologous group. Default PlasmoDB settings were used to consider positive signal peptide predictions: NN-Sum ≥ 3 or D-Score ≥ 0.5 or HMM probability ≥ 0.5. (B) Distribution of number of proteins per orthologous groups, varying from 2 to 5. (C) Proportion of groups showing at least one misannotated protein in each of the three classes: Negative (98/291), Positive (24/169) or Mixed (330/442), error bars= 95% confidence interval. Difference among multiple proportions was measured with the Chi-square test and the Marascuilo post-hoc analysis was used for testing differences between pairs of proportions (*** p<0.0001).Back to article page