Figure 7From: Improving N-terminal protein annotation of Plasmodium species based on signal peptide prediction of orthologous proteinsSignal peptide prediction patterns among Plasmodium species. (A) Three distinct patterns of signal peptide predictions were compared to a schematic phylogenetic tree (based on mitochondrial genes [59]) of five Plasmodium species to represent a likely evolutionary support. Pattern I: P. berguei and P. yoelii; Pattern II: P. vivax and P. knowlesi; Pattern III: P. falciparum. (B) The proportions of these three patterns were compared between groups that were originally Mixed but were reclassified because of either reannotations or optimization of signal peptide prediction parameters (N=301) and groups that have retained their classification as Mixed group despite inspections, reannotations and optimization (N=141). The Chi-square test was used to calculate statistical significance of the differences between proportions (* p<0.05, *** p<0.0001).Back to article page