Skip to main content

Advertisement

Figure 2 | Malaria Journal

Figure 2

From: An investigation of the auto-induction of and gender-related variability in the pharmacokinetics of dihydroartemisinin in the rat

Figure 2

Representative full-scan chromatograms of (A) a blank rat plasma sample; (B) a blank rat plasma sample spiked with dihydroartemisinin (DHA; 10 nM), artesunate (ARS; 10 nM), the glucuronide of DHA (DHA-G; 20 nM) and IS (QHS, 4 μM); (C) a rat plasma sample at 0.17 h after a single oral dose of DHA (10 mg/kg); and (D) a rat plasma sample at 0.17 h after a single oral dose of ARS (10 mg/kg). I: ARS ( m/z 402.2122); II: the glucuronide of DHA ( m/z 478.2283); III: DHA ( m/z 302.1962); IV: the monohydroxylated metabolite of DHA (M1; m/z 318.1911); V: IS ( m/z 283.1540).

Back to article page