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Table 1 The main pharmacokinetic parameters of dihydroartemisinin (DHA) and its phase I/II metabolites (M1 and DHA-G) after one-day and five-day oral administrations of DHA (10 mg/kg) to male (M) and female (F) rats (mean ± s.d)

From: An investigation of the auto-induction of and gender-related variability in the pharmacokinetics of dihydroartemisinin in the rat

  AUC0-t(nmolhL-1) Cmax(nmolL-1) Tmax(h) MRT (h) CL/F (L/min/kg)
One-day DHA M 1110.35 ± 724.56† 2062.22 ± 1364.13† 0.3 (0.2-0.5) 0.6 ± 0.1 0.75 ± 0.45†
F 322.16± 159.67† 562.71 ± 273.86† 0.3 (0.2-0.5) 0.6 ± 0.1 2.36 ± 1.40†
M1 M 1202.13± 418.50† 996.67 ± 244.81† 0.4 (0.3-0.5)† 1.0 ± 0.1† 0.53 ± 0.14†
F 191.46 ± 189.95† 180.02 ± 158.28† 0.5 (0.3-0.7)† 0.7 ± 0.1† 5.48 ± 3.98†
DHA-G M 855.69 ± 789.17† 1443.21 ± 1222.24† 0.3 (0.2-0.5) 0.6 ± 0.2† 1.78 ± 1.98†
F 58.16 ± 40.88† 236.11 ± 232.63† 0.2 (0.2-0.3) 0.3 ± 0.1† 10.43 ± 5.63*†
Five-day DHA M 1512.55 ± 950.76† 2605.58 ± 1677.94† 0.4 (0.2-0.7) 0.8 ± 0.3 0.72 ± 0.82†
F 212.63 ± 202.33† 378.05 ± 289.44† 0.3 (0.2-0.3) 0.6 ± 0.1 4.43 ± 2.83†
M1 M 2034.92± 903.13† 1102.67 ± 478.42† 0.5 (0.3-0.7) 1.3 ± 0.2† 0.35 ± 0.19†
F 157.11 ± 249.88† 153.58 ± 229.01† 0.6 (0.5-0.7) 0.7 ± 0.1† 8.77 ± 6.61†
DHA-G M 907.28 ± 542.38† 1155.90 ± 609.47† 0.3 (0.2-0.7) 1.0 ± 0.6† 0.82 ± 0.39†
F 19.33 ± 15.27† 125.30 ± 58.48† 0.2 (0.2-0.2) 0.2 ± 0.1† 20.49 ± 2.58†
  1. *: P < 0.05 (single dose compared with multiple dose); †: P < 0.05 (male rats compared with female rats).