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Table 1 Inhibition of Plasmodium falciparum W2 and recombinant falcipain-2 by Sorindeia juglandifolia extracts

From: Compounds from Sorindeia juglandifolia (Anacardiaceae) exhibit potent anti-plasmodial activities in vitro and in vivo

Fractions /Compounds Solvent system P. falciparum W2- IC50±SD (μg/ml) Falcipain-2 IC50±SD (μg/ml)
SJFR1   6.24±1.01 8.22±1.09
SJFR2 Hex:EtOAc 10% 11.55±2.45 6.02±3.81
SJFR3   >10 >10
SJFR4   >10 21.90 ±1.85
SJFR5 Hex:EtOAc 25% >10 >10
SJFR6   >10 >10
SJFR7   >10 >10
SJFR8   2.76±0.08 >10
SJFR9   2.30±0.97 5.42±0.65
SJFR10 Hex:EtOAc 50/50 2.46±0.29 >10
SJFR11   >10 >10
SJFR12   >10 >10
SJFR13   >10 >10
SJFR14   >10 >10
SJFR15 Hex:EtOAc 75% >10 17.31±2.51
SJFR16   >10 >10
SJFR17   8.47±0.41 1.12±0.16
SJFR18 EtOAc 100% >10 1.14±0.10
CQ   0.05±0.01  
ART   0.007±0.01  
E64   ND 0.049±0.003
2,3,6-trihydroxy benzoic acid (1)   16.47±0.47 μM 35.41±22.37μM
2,3,6-trihydroxy methyl benzoate (2)   13.04±1.63 μM 6.09±0.87 μM
  1. IC50= Concentration that killed/inhibited 50% of parasites/enzyme relative to negative control. S.D. = standard deviation, the drugs were tested in triplicate. Positive controls were CQ = chloroquine, ART= artemisinin, and E-64 = l-transepoxy-succinyl-leucylamido-(4-guanidino)-butane.