Table 2 Drugs that interact with sulphadoxine
Drug | Effect of Interaction |
|---|---|
Phenytoin | Serum hydantoin levels and risk of toxicity may be increased due to inhibition of hepatic metabolism by sulphadoxine |
Sulphonylureas (Glimepiride, Glyburide) | The hypoglycemic potential of the sulphonylureas may be increased; the mechanism of this interaction is unknown. |
Vitamin K antagonists (Coumadin, anisindione) | Co-administration with a sulphonamide may increase the plasma concentrations and hypoprothrombinemic effects of coumarin anticoagulants |
Gold salts | Increase the risk of blood dyscrasias |
Cyclosporine | Sulphadoxine decreases the serum concentration of cyclosporine while enhancing its nephrotoxic effect |